Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes

摘要: Abstract Objective: To determine correlates of clinical outcomes in patients with short bowel syndrome (SBS). Methods: Retrospective medical record review neonates treated between 1986 and 1998 who met our criteria for SBS: dependence on parenteral nutrition (PN) at least 90 days after surgical therapy congenital or acquired intestinal diseases. Results: Thirty subjects complete data were identified; 13 (43%) had necrotizing enterocolitis, 17 (57%) malformations. Mean (SD) residual small length was 83 (67) cm. Enteral feeding breast milk ( r = –0.821) an amino acid–based formula –0.793) associated a shorter duration PN, as longer –0.475) percentage calories received enterally 6 weeks surgery –0.527). Shorter time without diverting ileostomy colostomy 0.400), enteral protein hydrolysate –0.476), –0.504) lower peak direct bilirubin concentration. Presence intact ileocecal valve frequency catheter-related infections not significantly correlated PN. In multivariate analysis, only significant independent predictor less ostomy Conclusions: Although remains important PN use infants SBS, other factors, such formula, may also play role adaptation. addition, prompt restoration continuity is lowered risk cholestatic liver disease. Early both reduced cholestasis. (J Pediatr 2001;139:27-33)