Lipid Sorting and Multivesicular Endosome Biogenesis

摘要: Intracellular organelles, including endosomes, show differences not only in protein but also lipid composition. It is becoming clear from the work of many laboratories that mechanisms necessary to achieve such segregation can operate at very different levels, membrane biophysical properties, interactions with other lipids and proteins, turnover rates or distribution metabolic enzymes. In turn, directly influence organelle properties by changing parameters recruiting partner effector proteins involved sorting dynamics. this review, we will discuss how are sorted endosomal membranes they impact on endosome functions.