Helical rosette nanotubes: a more effective orthopaedic implant material

摘要: Due to the nanometric properties of some physiological components bone, nanomaterials have been proposed as next generation improved orthopaedic implant materials. Yet current efforts in design materials such titanium (Ti) are not aimed at tailoring their nanoscale features, which is now believed be one reason why Ti sometimes fails clinically a bone material. Much effort thus being dedicated developing bioactive surfaces and for biospecificity. Helical rosette nanotubes (HRN) new class self-assembled organic possessing biologically-inspired dimensions. Because chemical structural similarity with naturally-occurring nanostructured constituent collagen hydroxyapatite, we anticipated that an HRN-coated surface may simulate environment cells accustomed interacting with. The objective present vitro study therefore determine efficacy HRN prosthetic Results this clearly show both HRN-K1 HRN-Arg coated displayed enhanced cell adhesion when compared uncoated Ti. Enhanced was observed even concentrations low 0.005 mg ml−1. These results point towards possibilities tissue engineering they serve starting further mechanistic studies well future manipulation outer chemistries improve beyond those presented here. One incorporation peptide sequences on and/or growth factors known enhance functions.