Comparison of Outcomes of Phase II Studies and Subsequent Randomized Control Studies Using Identical Chemotherapeutic Regimens

摘要: Purpose To determine whether promising results from phase II studies could be reproduced in III studies, and to examine which characteristics of might predictive value for subsequent studies. Methods We searched all chemotherapy advanced solid malignancies, published the English language literature July 1998 June 2003. Each study was reviewed identify preceding Phase included this analysis must have used identical regimens. Data were extracted both Results Of 181 identified, 43 therapeutic regimens those 49 Twelve (28%) “positive.” The vast majority (81%) lower response rates than with a mean difference 12.9% among analyzed. None evaluated s...