Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking
作者： Ikramy A. Khalil , Kentaro Kogure , Shiroh Futaki , Hideyoshi Harashima
DOI: 10.1016/J.IJPHARM.2007.12.003
关键词:
摘要: Gene therapy is a promising new approach for treating variety of genetic and acquired diseases. While viral vectors are highly efficient gene therapy, their use associated with high toxicity immunogenicity. Synthetic or nonviral attractive alternatives to because low immunogenicity acute toxicity. The main disadvantage the transfection efficiency compared vectors. Novel functional devices enhance activities needed. In this review, we discuss modification liposomal drug carriers novel device, octaarginine (R8) peptide, delivery. Decoration liposomes R8 enhanced cellular uptake. addition, by optimizing density peptide as well its topology, could be internalized via clathrin-independent pathways, which improved intracellular trafficking through avoiding lysosomal degradation. A special emphasis given need conditions using not only uptake but also improve cargos. R8-modified nano-particles in delivery discussed.
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