A Convenient One-Step, High-Yield Preparation of Methylphosphonyl Dichloride from Dimethyl Methylphosphonate

作者: Kurt Moedritzer , R. E. Miller

DOI: 10.1080/00945717408069671

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摘要: Abstract Based on a 1H and 31P nmr study of the interactions alkyl-phosphonyl dichlorides, RP(O)Cl2, with dialkyl alkylphosphonates, RP(O)(OR)2, method was developed for preparation CH3P(O)Cl2 (R [dbnd] CH3) in 98% yield. This consists slow addition phosphonate to an excess refluxing SOCl2, thus suppressing irreversible side reactions. For R C2H5, yield 72% achieved; C4H9 ClCH2CH2 pure product could not be isolated.

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