Exploiting a new glycerol-based copolymer as a route to wound healing: Synthesis, characterization and biocompatibility assessment.

摘要: The use of biocompatible materials based on naturally derived monomers plays a key role in pharmaceutical and cosmetic industries. In this paper we describe the synthesis new low molecular weight copolymer, glycerol l-tartaric acid, useful to develop dermal patches with drug delivery properties. copolymer's chemical composition was assessed by FT-IR (Fourier transform infrared spectroscopy), (1)H NMR ((1)H Nuclear Magnetic Resonance) XPS (X-ray photoelectron while its distribution estimated SEC (size exclusion chromatography). Copolymer thermal properties were studied TGA (thermogravimetric analysis). Biological evaluations MTT assay SEM (scanning electron microscopy) observations performed murine fibroblasts human keratinocytes (HaCaT) revealed good compatibility proposed copolymer. Ciprofloxacin selected as model release evaluated HPLC (high performance liquid chromatography), showing that copolymer supplied promising results system for wound healing applications. Furthermore, investigations Skin-Mesenchymal stem cells (S-MSCs) behaviour gene expression showed combination ciprofloxacin did not affect their stemness. regard, fabrication new, cost local treatment skin infections represents an attractive strategy order bypass worrying side effects systemic antibiotic therapy. Overall, physico-chemical characterization, test biological could be tool situ bioactive molecules during lesions treatment.