Nano-hydroxyapatite-coated metal-ceramic composite of iron-tricalcium phosphate: Improving the surface wettability, adhesion and proliferation of mesenchymal stem cells in vitro

作者: Maria A. Surmeneva , Claudia Kleinhans , Gabriele Vacun , Petra Juliane Kluger , Veronika Schönhaar

DOI: 10.1016/J.COLSURFB.2015.07.057

关键词:

摘要: Thin radio-frequency magnetron sputter deposited nano-hydroxyapatite (HA) films were prepared on the surface of a Fe-tricalcium phosphate (Fe-TCP) bioceramic composite, which was obtained using conventional powder injection moulding technique. The coated Fe-TCP biocomposites (nano-HA-Fe-TCP) studied with respect to their chemical and phase composition, morphology, water contact angle, free energy hysteresis. deposition process resulted in homogeneous, single-phase HA coating. ability support adhesion proliferation human mesenchymal stem cells (hMSCs) biological short-term tests vitro. uncoated composite showed an initial cell attachment after 24h seeding, but adhesion, growth did not persist during 14 days culture. However, HA-Fe-TCP surfaces allowed days. nano-HA higher energy, improved hydrophilicity biocompatibility compared Fe-TCP. Furthermore, it is suggested that increase polar component responsible for enhanced case nano-HA-Fe-TCP biocomposites.

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