Effect of Acanthopanax senticosus on the accumulation of cadmium and on the immune response of spleen cells.

摘要: Exposure to cadmium (Cd) is known alter immune responses. Acanthopanax senticosus (Rupr. et Maxim.) Harms (AS) extract, an antioxidant-containing complex of phenolic compounds, tetracyclic triterpenoids/steroids, and polysaccharides, produce Cd mobilization excretion in vivo. Building upon earlier findings, the aim study was evaluate effects AS extract on accumulation changes presence splenic cells hosts during a chronic metal exposure. Chronic exposure BALB/c mice induced by providing them solutions containing different levels CdCl2 (25 or 250 mg/L) double-distilled water, with/without concurrent root (approximately 151 g material/L), for 8 wk. At end, spleen were measured. Levels key cells, including macrophages, T-lymphocytes, B-lymphocytes, determined immunohistochemistry using, respectively, CD68, CD3, CD20 antibodies. The results indicated that consumption high dose led significant decrease mouse spleen. lower less apparent. In addition, increased amount macrophages both B T lymphocytes relative concentrations lowered as result only intake.