Bactericidal Effect of Extracts and Metabolites of Robinia pseudoacacia L. on Streptococcus mutans and Porphyromonas gingivalis Causing Dental Plaque and Periodontal Inflammatory Diseases

摘要: The mouth cavity hosts many types of anaerobic bacteria, including Streptococcus mutans and Porphyromonas gingivalis, which cause periodontal inflammatory diseases dental caries. present study was conducted to evaluate the antibacterial potential extracts Robinia pseudoacacia its different fractions, as well some natural compounds against oral pathogens a nonpathogenic reference Escherichia coli. activity crude extract solvent fractions (hexane, chloroform, ethyl acetate butanol) R. were evaluated S. mutans, P. gingivalis E. coli DH5α by standard micro-assay procedure using conventional sterile polystyrene microplates. results showed that more active (100% growth inhibition) than (73% at 1.8 mg/mL. chloroform hexane with 91 97% inhibition, respectively, 0.2 None seven found in exerted an effect on gingivalis; however, fisetin myricetin 8 µg/mL inhibited 81% 86%, respectively. possesses bioactive could completely control gingivalis. antibiotic activities suggest are hydrophobic nature. indicate effectiveness plant clinical applications for treatment plaque use disinfectant various surgical orthodontic appliances.