Medulloblastoma—translating discoveries from the bench to the bedside

摘要: Medulloblastoma is a form of brain cancer that mainly arises during infancy and childhood. Our understanding this disease has transitioned rapidly; what was once thought as single entity now known to be compendium comprising at least four distinct subtypes tumour (Wnt, sonic hedgehog [SHH], group 3, 4 medulloblastomas) have characteristic molecular signatures, distinctive clinical features, are associated with different outcomes. Importantly, medulloblastomas occurring in infants (aged up 3 years) adults unique characteristics, which distinguish the from seen children aged >3 years. Accordingly, modern treatment approaches medulloblastoma integrate features enable provision most-effective therapies for each patient, reduce long-term sequelae. This Review discusses our current knowledge medulloblastoma. In particular, we present genetic histological patient demographics, prognosis, therapeutic options comprise entity. addition, adults, compared childhood and/or adolescent forms, described.