Pathophysiology of Activity Limitation in Patients With Interstitial Lung Disease

摘要: Objective To analyze the relative importance of gas exchange, ventilatory, and circulatory abnormalities in limiting exercise patients with interstitial lung disease. Design setting Retrospective study at a referral cardiopulmonary laboratory university/county medical center. Patients methods A database more than 1,300 incremental cycle studies was screened to find 42 disease, but without accompanying airflow limitation, chest wall, primary heart, or systemic vascular poor motivation. All had spirometry, volume, transfer index measures rest repeated during exercise; 37 multiple blood exercise. We graded dysfunction maximally tolerated ergometry correlated grades these three components respiration percent predicted peak O 2 uptake (peak Vo ). Results Peak V0 values were not well ventilatory impairment exchange dysfunction. who reduced often normal breathing reserve physiologic evidence pulmonary Conclusions The pathophysiology circulation is usually important mechanics