Changes in gene expression in the frontal cortex of rats with pilocarpine-induced status epilepticus after sleep deprivation
作者： Camila Hirotsu , Gabriela Matos , Sergio Tufik , Monica Levy Andersen , None
DOI: 10.1016/J.YEBEH.2013.02.024
关键词:
摘要: Sleep and epilepsy present a bidirectional interaction. complaints are common in epilepsy, sleep deprivation may provoke seizures. However, the mechanisms underlying this relationship unknown. Thus, study investigated effects of paradoxical (PSD24h) total (TSD6h) expression genes related to reactive oxygen species nitric oxide production frontal cortex rodent model temporal lobe (PILO). The data show that PILO rats had increased NOX-2 decreased SOD expression, independent sleep. Higher was observed only subjected control condition TSD6h. Also, eNOS DDAH1 were group submitted Moreover, CAT PSD24h reduced compared not sleep-deprived. molecular changes found following suggest mechanism via oxidative stress.
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