Effect of Dietary Phytic Acid on Hepatic Activities of Lipogenic and Drug-Metabolizing Enzymes in Rats Fed 1,1,1-trichloro-2,2-bis (P-chlorophenyl) Ethane (DDT)

摘要: This study was conducted to examine the influence of dietary sodium phytate (10.2g/kg diet) on hepatic activities lipogenic and drug-metabolizing enzymes in rats fed 1,1,1-trichloro-2,2-bis (P-chlorophenyl) ethane (DDT) (0.7g/kg diet). Dietary DDT enhanced lipids, elevated enzymes, increased serum levels cholesterol phospholipid, raised enzymes. significantly decreased rises lipids due feeding. The enhancement activity phase II enzyme, glutathione S-transferase, that had been caused by feeding with phytate. These results suggest can protect DDT-fed animals against an accumulation depressing lipogenesis. present also implies might improve function exposed DDT.