Peculiarities and possible mode of actions of thalidomide

摘要: Thalidomide is a Janus-faced substance par excellence. It may be argued that two-sided behavior typical for all substances, exhibiting beneficial and adverse effects simultaneously or at least different dose ranges. However, in the case of thalidomide situation somewhat different. On one hand, was marketed advertised as being “atoxic,” deduced from animal studies performed routinely time, during very extensive therapeutic use between 1957 1962 few were reported humans; even several attempted suicides with overdoses unsuccessful. other this responsible largest health outcome ever caused by an agent doses short marketing period.