Expression of adhesion receptors on rat limb bud cells and results of treatment with a thalidomide derivative.
作者： Renate Thiel , Ursula Kastner , Reinhard Neubert
DOI: 10.1016/S0024-3205(99)00571-8
关键词: Endocrinology 、 Limb bud 、 Callithrix 、 CD18 、 Biology 、 Transferrin receptor 、 Thalidomide 、 Internal medicine 、 Integrin alpha M 、 Receptor 、 Integrin
摘要: Abstract The expression of several adhesion surface receptors was studied on cells early limb bud development 58 Wistar rats treated orally with two daily doses the thalidomide derivative EM12 (2 × 50 mg kg body weight) from day 7 to 10 pregnancy. is a more potent teratogen than thalidomide. Limb 56 untreated animals served as controls. studies revealed that integrins CD11a, CD11b, CD18, CD49d, and CD61, well additional CD54, CD62L, transferrin receptor CD71 were expressed 11 gestation various degrees these embryonic cells. In contrast results previous non-human primate (Callithrix jacchus) there no down-regulation any rat embryos after treatment EM12. This result in accordance lack teratogenicity this rodent species.
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