Sensitivity of CaM Kinase II to the Frequency of Ca2+Oscillations
作者： Paul De Koninck , Howard Schulman , None
DOI: 10.1126/SCIENCE.279.5348.227
关键词:
摘要: The transduction of many cellular stimuli results in oscillations the intracellular concentration calcium ions (Ca2+). Although information is thought to be encoded frequency such oscillations, no decoder has been identified. Rapid superfusion immobilized Ca2+- and calmodulin-dependent protein kinase II (CaM II) vitro showed that enzyme can decode Ca2+ spikes into distinct amounts activity. response CaM was modulated by several factors, including amplitude duration individual as well subunit composition previous state activation kinase. These features should provide specificity this multifunctional may underlie its pivotal role activity-dependent forms synaptic plasticity.
sciencemag.org
harvard.edu参考文章(50)
ROGER P. ESTEP, KENNETH A. ALEXANDER, DANIEL R. STORM, Regulation of Free Calmodulin Levels in Neurons by Neuromodulin: Relationship to Neuronal Growth and Regeneration Current Topics in Cellular Regulation. ,vol. 31, pp. 161- 180 ,(1990) , 10.1016/B978-0-12-152831-7.50006-8
S. Mukherji, T.R. Soderling, Regulation of Ca2+/calmodulin-dependent protein kinase II by inter- and intrasubunit-catalyzed autophosphorylations. Journal of Biological Chemistry. ,vol. 269, pp. 13744- 13747 ,(1994) , 10.1016/S0021-9258(17)36708-X
R W Holl, M O Thorner, G L Mandell, J A Sullivan, Y N Sinha, D A Leong, Spontaneous oscillations of intracellular calcium and growth hormone secretion. Journal of Biological Chemistry. ,vol. 263, pp. 9682- 9685 ,(1988) , 10.1016/S0021-9258(19)81571-5
M MacNicol, A B Jefferson, H Schulman, Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells. Journal of Biological Chemistry. ,vol. 265, pp. 18055- 18058 ,(1990) , 10.1016/S0021-9258(17)44711-9
B L Patton, S G Miller, M B Kennedy, Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain. Journal of Biological Chemistry. ,vol. 265, pp. 11204- 11212 ,(1990) , 10.1016/S0021-9258(19)38577-1
P.I. Hanson, H Schulman, Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis. Journal of Biological Chemistry. ,vol. 267, pp. 17216- 17224 ,(1992) , 10.1016/S0021-9258(18)41915-1
R.J. Colbran, Inactivation of Ca2+/calmodulin-dependent protein kinase II by basal autophosphorylation. Journal of Biological Chemistry. ,vol. 268, pp. 7163- 7170 ,(1993) , 10.1016/S0021-9258(18)53160-4
Ricardo E. Dolmetsch, Keli Xu, Richard S. Lewis, Calcium oscillations increase the efficiency and specificity of gene expression Nature. ,vol. 392, pp. 933- 936 ,(1998) , 10.1038/31960
Wen-hong Li, Juan Llopis, Michael Whitney, Gregor Zlokarnik, Roger Y. Tsien, Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression Nature. ,vol. 392, pp. 936- 941 ,(1998) , 10.1038/31965
L Brocke, M Srinivasan, H Schulman, Developmental and regional expression of multifunctional Ca2+/calmodulin-dependent protein kinase isoforms in rat brain The Journal of Neuroscience. ,vol. 15, pp. 6797- 6808 ,(1995) , 10.1523/JNEUROSCI.15-10-06797.1995