EGFR and NF-κB: partners in cancer

摘要: Oncogenic proteins cooperate to promote tumor development and progression by sustaining cell proliferation, survival invasiveness. Constitutive epidermal growth factor receptor (EGFR) nuclear κb (NF-κB) activities are seen in multiple solid tumors combine provide oncogenic signals cancer cells. Understanding how these pathways connected is crucial, given their role intrinsic or acquired resistance targeted anticancer therapies. We review molecular mechanisms which both EGFR- NF-κB-dependent establish positive loops increase potential. also describe NF-κB promotes EGFR inhibitors.