Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach
作者： Neha Nanda , Devinder K. Dhawan , Alka Bhatia , Akhtar Mahmood , Safrun Mahmood
DOI: 10.1371/JOURNAL.PONE.0151539
关键词:
摘要: Background Doxycycline (DOX) exhibits anti-inflammatory, anti-tumor, and pro-apoptotic activity is being tested in clinical trials as a chemotherapeutic agent for several cancers, including colon cancer. Materials & Methods In the current study, of doxycycline was rat model carcinogenesis, induced by specific cancer promoter, 1,2, dimethylhydrazine (DMH) well study effect DOX-alone on separate group rats. Results administration DMH-treated rats (DMH-DOX) unexpectedly increased tumor multiplicity, stimulated progression colonic growth from adenomas to carcinomas revealed metastasis small intestine determined macroscopic histopathological analysis. treatment showed markedly enhanced chronic inflammation reactive hyperplasia, which dependent upon dose administered. Moreover, immunohistochemical analysis evidence anti-apoptotic action DOX deregulation various biomarkers. Conclusion These results suggest that caused colon, injury, efficacy DMH provided mechanistic link between doxycycline-induced tumorigenesis. Ongoing studies thus may need focus molecular mechanisms action, lead its inflammatory tumorigenic effects.
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