Coagulation in hepatobiliary disease

摘要: Objective To review the pathogenesis and clinical consequences of coagulation abnormalities accompanying hepatobiliary disorders to highlight need for further studies characterize these derangements their treatment options in small animal patients. Data Sources Veterinary human medical literature: original research articles, scientific reviews, consensus statements, recent texts. Summary The liver plays an important role production clearance many components coagulation. A wide range hemostatic can occur patients with disease including alterations platelet number function, factor levels, anticoagulants, vascular endothelial fibrinolysis. As include both pro- anticoagulation pathways, net result is often a rebalanced system that be easily disrupted by concurrent conditions resulting either bleeding or thrombosis. Conventional tests are inadequate at identifying spectrum occurring disease, but evaluation necessary assess risk provide prognostic information. paucity information exists regarding animals disease. Extrapolation from provides some about potential options, warranted this area elucidate best management dogs cats disease. Conclusion Hepatobiliary have profound effects on function leading hypercoagulable hypocoagulable states. Overall status depends type severity presence associated complications.