16α-[18F]Fluoro-17β-estradiol

摘要: Estrogens and progestins are endogenous hormones that produce many physiological effects. act primarily by regulating gene expression. Estrogen receptors found in the cell nucleus of female reproductive tract, breast, pituitary, hypothalamus, bone, liver, other tissues, also various tissues men. lipophilic they enter passively diffusion through cellular membrane. They bind to estrogen present nucleus.Breast cancer is most common malignancy women. About 33% women who have this disease will die disseminated breast cancer. The growth epithelial cells dependent on stimulation induce progestin receptor Two-thirds carcinomas express ERs. It has been established ER status tumor an important prognostic indicator (1). Women with ER-positive tumors a better prognosis than ER-negative terms responsiveness anti-estrogen treatment. content was assessed binding assays, which suffer from inter-assay variability limited intrinsic heterogeneity tumor. 16α-[18F]Fluoro-17β-estradiol ([18F]FES) proven be valuable tracer for studies primary metastatic (2).