Positron Tomographic Assessment of Estrogen Receptors in Breast Cancer: Comparison with FDG-PET and In Vitro Receptor Assays

摘要: The purpose of this study was to assess the results PET with 16{alpha}-[{sup 18}F]fluoro-17 {beta}-estradiol (FES) and [{sup 18}F]fluoro-2-deoxy-D-glucose (FDG) validate concordance between tumor estrogen-receptor (ER) status as determined by FES-PET in vitro assays relationship metabolic activity FDG-PET ER status, both which may provide information about aggressiveness prognosis. We studied 32 patients primary breast masses 21 clinical or radiological evidence recurrent/metastic carcinoma. A diagnosis carcinoma subsequently proven 43 (24 primary, 15 metastic 4 recurrent tumors). In assessment available for 40 malignant lesions (23 17 metastatic/recurrent). underwent FES FDG, uptake each tracer within lesion evaluated qualitatively well semiquantitatively using standardized-uptake-value (SUV) method. found good overall agreement (88%) FES-PET. This degree is similar that observed replicate (with discordances due interlaboratory, interassay specimen variability). were, however, unable demonstrate any significant FDG uptakemore » these patients. These indicate and/or unique direct cancer cannot be obtained indirectly FDG-PET. 25 refs., 5 figs., 2 tabs.« less