Identification of noradrenergic nerve terminals immunoreactive for neuropeptide Y and vasoactive intestinal peptide in the rat kidney.
作者： D. S. Knight , R. D. Fabre , J. A. Beal
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摘要: Cryostat-and vibratome-cut sections of rat kidneys were singly or doubly labeled to visualize immunoreactive tyrosine hydroxylase (THI), dopamine beta-hydroxylase (DBHI), vasoactive intestinal peptide (VIPI), and neuropeptide Y (NPYI). Rats perfusion fixed with 2-4% paraformaldehyde without 0.15% picric acid rinsed in buffer for 18-48 hr. Single antigens horseradish per-oxidase vibratome sections, whereas cryostat used label one antigen perox-idase another a fluorophore the same tissue section. A dense plexus DBHI noradren-ergic nerves innervates renal arterial tree, such innervate interlobar veins calyx as well. Immunoreactive NPY is colocal-ized most these nerves, but some intrarenal noradrenergic do not contain VIP immunoreactivity. The distribution NPYI resembles that perivascular selected arcuate interlobular arteries. small population nonadrenergic, VIPI calyx.
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