Extended angiotensin converting enzyme inhibition changes the innervation of renal glomerular afferent arterioles

摘要: Abstract Chronic inhibition of the angiotensin I converting enzyme (ACE) with enalapril, results in a phenotypic change medial cells renal afferent arterioles from contractile smooth muscle to renin containing epithelioid cells. In normal animals, density innervation juxtaglomerular is much lower compared The effector tissues are known play an important role determining pattern and their innervation. this study, we tested hypothesis that arteriole decreases when they phenotype show had significantly increased association terminals changed. There were more varicosities around rabbits treated enalapril (10 μg/kg/h) for 6 weeks (mean±SEM=634±175×103/mm2 vessel surface, cf. 329±69×103/mm2 surface untreated rabbits, P=0.05), number neuroeffector junctions remaining same (124±14 164±32×103/mm2 surface) non-contacting (i.e. lying>100 nm cells) (74±5% 25±7%, respectively; P=0.003). Thus, there was no reduction which changed response treatment as hypothesised. Instead, it would appear proliferation occurred, formation additional but these failed form neuromuscular junctions. This study has identified neural plasticity kidney not previously been described.