Inhibition of the renin-angiotensin system: effects on tachycardia-induced early electrical remodelling in rabbit atrium:
作者： Roman Laszlo , Christian Eick , Norman Rueb , Slawomir Weretka , Hans-Joerg Weig
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摘要: Introduction.Tachycardia-induced atrial remodelling (as an equivalent to fibrillation) can be influenced by the renin-angiotensin system. Effects of a seven-day enalapril pre-treatment (EPT, 0.16 mg/kg body weight subcutaneously every 24 h) on ionic currents underlying tachycardia-induced early electrical after h rapid pacing (RAP, 600 beats/min) in rabbit atrium were studied. Materials and methods. Animals divided into four groups (n =4 each): control; paced only; paced, respectively. Using patch-clamp technique whole-cell mode, current densities
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