Angiotensin receptors and development: the kidney.
作者： Daine Alcorn , Jane E McCausland , Christine Maric
DOI: 10.1111/J.1440-1681.1996.TB02819.X
关键词:
摘要: 1. This brief review examines the evidence that angiotensin II (AngII) is essential for kidney development. 2. Several components of renin-angiotensin system (RAS) are detected in foetal early 3. Angiotensin normal and neonatal renal function. 4. receptors transduce important signals leading to growth 5. receptor subtypes show spatial temporal specificity localization throughout 6. converting enzyme (ACE) inhibition or AngII blockade (specifically AT1 subtype blockade) results functional structural abnormalities developing both experimental clinical situations. 7. While chronic postnatal RAS rats associated with damage tubules blood vessels kidney, reports differ on whether treatment also affects glomerular induction growth. 8. In metanephric organ culture, proceeds despite blockade. 9. summary, suggests not nephron development rat kidney. However, vasculature.
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