Trophic interactions between rat nerves and blood vessels in denervated peripheral arteries and in anterior eye chamber transplants.

摘要: This investigation was undertaken to examine trophic interrelationships between nerves and arteries in male Wistar rats. Two approaches were used. (1) Surgical denervation of two peripheral muscular the thigh (the superficial epigastric saphenous) carried out on young animals (5-20 days old). (2) Arteries from adults, either with a high density innervation situ tail artery), or virtually uninnervated femoral transplanted into intact sympathectomized anterior eye chambers adult rat hosts. In experiments, maximum length time before reinnervation occurred 15 postoperatively. The only evidence morphological change vessel wall external elastic lamina that became irregular laminated. Reinnervation followed typical developmental sequence, accelerated younger by double lesion. Translocating proximal part nerve carrying vasomotor indicated sprouting directional toward arteries, bypassing an artery very sparse innervation. transplant experiments chamber showed densely innervated artery) could induce iridean sprouting. artery, lacking adrenergic iris, reinnervated terminals small agranular vesicles. These vesicles Schwann cell complexes, at similar relative density, occupying same position wall, as ingrowing fully iris. latter also had proportion clear A population large granular be found both types terminals. Therefore, tissue normally having sympathetic cannot assumed completely noninnervated when chamber. described here demonstrated presence interactions but revealed heterogeneity response vessels extremely low levels situ.