Heart rate variability is associated with polymorphic variation in the choline transporter gene.
作者： Serina A. Neumann , Elizabeth C. Lawrence , J Richard Jennings , Robert E. Ferrell , Stephen B. Manuck
DOI: 10.1097/01.PSY.0000155671.90861.C2
关键词:
摘要: OBJECTIVE The objective of this study was to determine whether interindividual variation in parasympathetic (cholinergic) and sympathetic (adrenergic) regulation heart rate (as estimated by frequency components variability [HRV]) may be accounted for, part, genetic the choline transporter, a component acetylcholine neurotransmission. METHODS Resting HRV estimates high- (HF) low-frequency (LF) power LF/HF ratio were determined from electrocardiogram recordings collected continuously over 5 minutes 413 white individuals European ancestry (49% men; aged 30-54 years [mean, 44 years]). Subjects genotyped for single nucleotide polymorphism (SNP) located 3' untranslated region transporter gene (CHT1). Frequencies alternate CHT1 alleles, labeled G T, 76% 24%. RESULTS Compared with GG homozygotes, participants having any T allele had greater HF (p <.02), lower LF ratios <.005). Relative men, women <.001) CONCLUSIONS These findings show that polymorphic is associated significantly indices related activity.
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