Vitamin D and calcium deficits predispose for multiple chronic diseases.

摘要: There is evidence from both observational studies and clinical trials that calcium malnutrition hypovitaminosis D are predisposing conditions for various common chronic diseases. In addition to skeletal disorders, vitamin deficits increase the risk of malignancies, particularly colon, breast prostate gland, inflammatory autoimmune diseases (e.g. insulin-dependent diabetes mellitus, bowel disease, multiple sclerosis), as well metabolic disorders (metabolic syndrome, hypertension). The aim present review was provide improved understanding molecular cellular processes by which in cause specific changes cell organ functions thereby different aetiology. 1,25-Dihydroxyvitamin D(3) extracellular Ca(++) key regulators proliferation, differentiation function at level. However, efficiency receptor-mediated intracellular signalling limited negative effects on extrarenal 25-hydroxyvitamin D-1alpha-hydroxylase activity thus production 1,25-dihydroxyvitamin D(3). Calcium eventually causes a decrease concentration fluid compartments, resulting organ-specific modulation calcium-sensing receptor activity. Hence, attenuation signal transduction ligand-activated seems be prime mechanism insufficiencies perturbation bone, kidney, intestine, mammary glands, endocrine pancreas, vascular endothelium, and, importantly, immune system. wide range associated with combination high prevalence these represents special challenge preventive medicine.