The Effects of Adulterating Agents on FPIA Analysis of Urine for Drugs of Abuse

摘要: A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs abuse. Sixteen different agents, at concentrations up 10%, tested against urine assays cannablnolds, cocaine (metabolite), amphetamines, opiates, phencyclidlne (PCP), and barbiturates. The potential cause both false positive negative results was evaluated, performed one seven days after sample adulteration simulate collection/testing formats. All six drug susceptible or more adulterating but the degree varied considerably between assays. cannabinoid assay most adulterantinduced results, barbiturate results. remaining demonstrated relatively few, characteristic effects, some which attributable degradation others interference. Although pH measurement adulterated samples verified its utility in identifying with interfering other adulterants that substantial would not be identified by measurements alone.