Lymphocyte function in human bone marrow. II. Characterization of an interleukin 2-sensitive T precursor-cell population.

摘要: In the present study of human bone marrow lymphocytes, we analyze a newly recognized population T suppressor-cell precursors which are found in only and have potential to inhibit immunoglobulin (Ig) productionin vitro. Following exposure interleukin 2 (IL2), suppressor acquire E receptor, T3 determinants, function, lectin responsiveness. To distinguish this within framework T-cell ontogeny, it was compared previously described thymus-dependent helper express function following thymus-derived mediators. The two populations completely distinct can be separated on density gradients. Suppressor expressed T8 TAC (IL2-receptor) antigens prior toin vitro induction with IL2. thymic hormone-dependent cells T4 but not or determinants. patients severe combined immunodeficiency disease (SCID), IL2-responsive precursor appeared late after thymus epithelium transplantation, perhaps best explained by model differentiation pathways precede, induce, seed extrathymic differentiation. large pool size over 1011 adult suggests that these may play an important role immune homeostasis.