miRNAs as therapeutic targets in cancer
作者： Bo Song , Jingfang Ju , Yuan Wang
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摘要: MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3' untranslated regions (UTRs) their target mRNAs. The invention relates to application miR-192 and miR-215. Both these miRNAs impact cellular proliferation through p53-miRNA circuit, interact dihydrofolate reductase (DHFR) thymidylate synthase (TS). Particularly, upregulation reduces proliferation. this discovery. For example, inhibiting and/or miR-215 sensitizes neoplasm or subject chemotherapeutic agents. Furthermore, measuring levels provides one information regarding whether will respond Accordingly, composition methods relating identification, characterization modulation
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