Peritoneal Glucose Exposure and Changes in Membrane Solute Transport with Time on Peritoneal Dialysis

摘要: Abstract . Peritoneal solute transport increases with time on treatment in a proportion of peritoneal dialysis (PD) patients, contributing to ultrafiltration failure. Continuous exposure the peritoneum hypertonic glucose solutions results morphologic damage that may have causative role changes function. The purpose this analysis was establish whether increased preceded selected group long-term PD patients. transport, residual renal function, peritonitis rate, and were recorded prospectively cohort 303 patients at single center. A subgroup individuals, treated continuously for 5 yr, identified defined retrospectively as having either stable or increasing status. Of 22 who 13 had (solute start, 0.67 [±0.1]; [±0.1]), whereas 9 sustained increase 0.56 [±0.08]; 0.77 [±0.09]). Compared those earlier loss function exposed significantly more during first 2 yr transport. This associated greater achieved compensating reduced urinary volumes these Further observed continued rise. Peritonitis, including severity infection organism, similar both groups. In survivors PD, an by glucose. is supportive evidence play alterations membrane