摘要: This review presents a survey on functional soluble polymers in view of their use as supports for liquid-phase synthesis. The general aspects synthesis homogeneous media well analytical and separation problems are discussed, focussing the role polymer synthetic cycle associated with polymer-supported reactions. A polymeric carriers respect groups backbones is provided an emphasis poly(oxyethylene), polystyrene, poly(vinyl alcohol) supports. Combined methods using solid also highlighted. discussed evaluated peptide nucleotide Finally outlook into future developments attempted.
springer.com
springerlink.com参考文章(127)
Robert L. Letsinger, V. Mahadevan, Oligonucleotide Synthesis on a Polymer Support1,2 Journal of the American Chemical Society. ,vol. 87, pp. 3526- 3527 ,(1965) , 10.1021/JA01093A058
R. B. Merrifield, Solid phase peptide synthesis. I. the synthesis of a tetrapeptide Journal of the American Chemical Society. ,vol. 85, pp. 2149- 2154 ,(1963) , 10.1021/JA00897A025
H. Kossel, M. W. Moon, H. G. Khorana, Studies on Polynucleotides. LX.1 The Use of Preformed Dinucleotide Blocks in Stepwise Synthesis of Deoxyribopolynucleotides2 Journal of the American Chemical Society. ,vol. 89, pp. 2148- 2154 ,(1967) , 10.1021/JA00985A030
L. Russell. Melby, Donald R. Strobach, Oligonucleotide Syntheses on Insoluble Polymer Supports. I. Stepwise Synthesis of Trithymidine Diphosphate Journal of the American Chemical Society. ,vol. 89, pp. 450- 453 ,(1967) , 10.1021/JA00978A052
Robert L. Letsinger, Milton J. Kornet, Popcorn Polymer as a Support in Multistep Syntheses Journal of the American Chemical Society. ,vol. 85, pp. 3045- 3046 ,(1963) , 10.1021/JA00902A054
M. J. Gait, R. C. Sheppard, A polyamide support for oligonucleotide synthesis Journal of the American Chemical Society. ,vol. 98, pp. 8514- 8516 ,(1976) , 10.1021/JA00442A033
Kurt Geckeler, Ernst Bayer, Functionalization of soluble polymers: 3. Preparation of carboxy-telechelic polymers Polymer Bulletin. ,(1980) , 10.1007/BF00255094
Robert L. Letsinger, V. Mahadevan, Stepwise synthesis of oligodeoxyribonucleotides on an insoluble polymer support. Journal of the American Chemical Society. ,vol. 88, pp. 5319- 5324 ,(1966) , 10.1021/JA00974A053
Hikoya Hayatsu, H. G. Khorana, Deoxyribooligonucleotide Synthesis on a Polymer Support1 Journal of the American Chemical Society. ,vol. 88, pp. 3182- 3183 ,(1966) , 10.1021/JA00965A086
V. Amarnath, A. D. Broom, Chemical synthesis of oligonucleotides ChemInform. ,vol. 8, pp. 183- 217 ,(1977) , 10.1021/CR60306A002