Sensory irritation of vapours of formic, acetic, propionic and butyric acid.

摘要: Abstract In mice, inhalation of formic, acetic, propionic and butyric acid caused a rapid decrease in the respiratory rate, which decreased to stable level during remaining part 30 min exposure period; this was due sensory irritation. The concentration decreasing rate (RD) by 50% (RD50) 438, 308, 386 285 ppm, respectively, allowed an adequate prediction Threshold Limit Values. mice inhaling through tracheal cannula, bypassing trigeminal nerves, slower pulmonary low range, irritation response less pronounced than response. As normal (non-cannulated) not influenced irritation, is key effect, presumably scrubbing effect upper airways, preventing access lungs. activated receptors were non-lipophilic (hydrophilic) environment, from where may be means liberated protons. At RD0, formic may, at least partly, activates ASIC, TRPV1 TRPA1 receptors, whereas activate ASIC based on estimated pH mucus layer.