A biocompatible flow chamber to study the hemodynamic performance of prosthetic heart valves.
作者： Wei Yin , Ek Ching Ngwe , David A. Rubenstein
DOI: 10.1097/MAT.0B013E31826140A2
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摘要: The goal of this study was to design, fabricate, and characterize a biocompatible flow chamber the performance artificial heart valves. system consists testing fluid water (separated by latex diaphragm), following design left ventricular assist device. Two St. Jude bileaflet mechanical valves were placed oppositely in control direction. rate set at 5.6 L/min, with stroke volume 80 ml. examined through three-dimensional numerical simulation vitro experiments whole blood washed platelets. Hemolysis measured using spectrophotometer. Platelet activation platelet surface P-selectin expression cytometry. computational dynamics model demonstrated that field laminar physiological. Results from indicated conditions did not induce hemolysis or presence Overall, can provide feasible environment hemodynamic
wkhealth.com参考文章(20)
S. Laustriat, S. Geiss, F. Becmeur, J. Bientz, L. Marcellin, P. Sauvage, Medical history of Teflon. European Urology. ,vol. 17, pp. 301- 303 ,(1990) , 10.1159/000464065
Jagdish Butany, Manmeet S. Ahluwalia, Craig Munroe, Cristina Fayet, Christina Ahn, Patrick Blit, Charis Kepron, Roberto J. Cusimano, Richard L. Leask, Mechanical heart valve prostheses: identification and evaluation (erratum). Cardiovascular Pathology. ,vol. 12, pp. 322- 344 ,(2003) , 10.1016/S1054-8807(03)00105-4
Ned H C Hwang, Xu Lijun, Yeo Joon Hock, Bubble observation and transient pressure signals in mechanical heart valve cavitation study. Journal of Heart Valve Disease. ,vol. 12, pp. 235- 244 ,(2003)
M.R. Hardeman, J.F. Antaki, S.S. Lee, K.H. Ahn, N.J. Kim, S.J. Lee, J.G. Dobbe, K. Sun, Association between arterial stiffness and the deformability of red blood cells (RBCs) Clinical Hemorheology and Microcirculation. ,vol. 34, pp. 475- 481 ,(2006)
Lawrence S.C. Czer, Mason Weiss, Timothy M. Bateman, J. Martin Pfaff, Michele DeRobertis, Neal Eigler, Ran Vas, Jack M. Matloff, Richard J. Gray, Fibrinolytic therapy of St. Jude valve thrombosis under guidance of digital cinefluoroscopy. Journal of the American College of Cardiology. ,vol. 5, pp. 1244- 1249 ,(1985) , 10.1016/S0735-1097(85)80032-2
P.Y. Huang, J.D. Hellums, Aggregation and disaggregation kinetics of human blood platelets: Part II. Shear-induced platelet aggregation. Biophysical Journal. ,vol. 65, pp. 344- 353 ,(1993) , 10.1016/S0006-3495(93)81079-8
Keefe B. Manning, Vinayak Kini, Arnold A. Fontaine, Steven Deutsch, John M. Tarbell, Regurgitant flow field characteristics of the St. Jude bileaflet mechanical heart valve under physiologic pulsatile flow using particle image velocimetry Artificial Organs. ,vol. 27, pp. 840- 846 ,(2003) , 10.1046/J.1525-1594.2003.07194.X
Lakshmi P Dasi, Helene A Simon, Philippe Sucosky, Ajit P Yoganathan, FLUID MECHANICS OF ARTIFICIAL HEART VALVES Clinical and Experimental Pharmacology and Physiology. ,vol. 36, pp. 225- 237 ,(2009) , 10.1111/J.1440-1681.2008.05099.X
F. De Somer, L. Foubert, M. Vanackere, D. Dujardin, J. Delanghe, G. Van Nooten, Impact of oxygenator design on hemolysis, shear stress, and white blood cell and platelet counts Journal of Cardiothoracic and Vascular Anesthesia. ,vol. 10, pp. 884- 889 ,(1996) , 10.1016/S1053-0770(96)80050-4
Wei Yin, Saravan Kumar Shanmugavelayudam, David A. Rubenstein, The effect of physiologically relevant dynamic shear stress on platelet and endothelial cell activation Thrombosis Research. ,vol. 127, pp. 235- 241 ,(2011) , 10.1016/J.THROMRES.2010.11.021