Implications of pharmacogenomics for drug development and clinical practice.

摘要: Pharmacogenomics is likely to be among the first clinical applications of Human Genome Project and certain have an enormous impact on practice medicine. Herein, we discuss potential implications pharmacogenomics drug development process, including safety, productivity, market segmentation, expansion, differentiation, personalized health care. We also review 3 challenges facing translation into practice: dependence information technology, limited care financing, scientific uncertainty surrounding validation specific technology. To our knowledge, there currently no formal agenda promote cultivate innovation, develop progressive or obtain financing that would required advance use pharmacogenomic technologies in patient Although these driving change sciences, it remains seen which systems level needs will addressed.