Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy.

摘要: Because clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous for neuroprotection. Two mechanisms characterized so far, namely ischemic preconditioning and postconditioning. The concept is based on observation that a brief, noninjurious episode ischemia able protect brain from subsequent longer insult. Recently, hypothesis offered modified reperfusion prolonged may also confer neuroprotection, phenomenon termed Many pathways proposed as plausible explain neuroprotection by Unfortunately, none them clearly identified mechanism involved present article will review main reported date effect both