K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.

摘要: Mutations involving the K-ras proto-oncogene are believed to play an important role in mechanism of tumorigenesis for many human cancers and occur 10-30% endometrial carcinomas. In present study 221 cases endometrioid carcinoma obtained from Japanese patients with average follow-up 41 months were examined point mutations codon 12 through use polymerase chain reaction. 103 lymph node dissection had been performed. significantly associated presence metastases (P 60 years, postmenopausal). postmenopausal age group (>60 years), was statistically who died or experienced recurrence (41.2% vs 13.0%; P < 0.03). This related a dramatic (greater than eightfold; = 0.011) increase likelihood adverse outcome between premenopausal states whose tumors contained mutant K-ras. These findings possible activation mechanism(s) responsible more aggressive clinical behavior cancer that is observed patients.