Isolation and characterization of eca1, a gene overexpressed in endometrioid carcinomas of ovary and endometrium

摘要: This invention provides an isolated polynucleotide encoding ECA1 polypeptide. Also provided is the polypeptide Further antibody that specifically recognizes and binds or epitope thereof. The polynucleotides, antibodies and/or polypeptides of this may be components compositions, host cells gene delivery vehicles, where appropriate. In one aspect, cell will produce recombinant ECA1, which further defined herein. another antigen presenting such as a dendritic cell, it display antigenic portion on its surface. polypeptides, proteins compositions are useful to aid in diagnosis neoplastic condition endometrioid origin. method comprises detecting presence overexpressed proto-oncogene sample suspected containing said wherein overexpression indicative cell. These include, but not limited ovarian colon carcinoma cells.