TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

摘要: Although it is recognized that three isoforms of transforming growth factor-beta (TGF-beta) exist in mammals, their expression, distribution, and function injury repair are not well characterized. Using immunohistochemistry antibodies to synthetic peptides TGF-beta 1, 2, 3, we determined the distribution lung sections with acute chronic lesions idiopathic pulmonary fibrosis (IPF), asbestosis hypersensitivity pneumonitis, as non-specific pneumonitis. In advanced honeycombing, irrespective diagnosis, 1 was prominently expressed epithelial cells macrophages found be associated extracellular matrix. lungs early IPF only inflammatory changes, present alveolar but cells. Small amounts matrix-associated were subepithelially areas from patients minimal inflammation no fibrosis. normal evidence or seen macrophages, cells, extracellularly. 2 3 smooth muscle vessels bronchi both fibrotic changes. Our findings suggest while ubiquitously lung, where presence disease-specific an indication chronicity injury.