Transmission of hepatitis E virus from rabbits to cynomolgus macaques.
作者： Peng Liu , Qiu-Ning Bu , Ling Wang , Jian Han , Ren-Jie Du
关键词:
摘要: The recent discovery of hepatitis E virus (HEV) strains in rabbits the People’s Republic China and United States revealed that are another noteworthy reservoir HEV. However, whether HEV from can infect humans is unclear. To study zoonotic potential for pathogenesis rabbit HEV, we infected 2 cynomolgus macaques with an strain China. Typical developed both monkeys; they exhibited elevated liver enzymes, viremia, shedding fecal specimens, seroconversion. Comparison complete genome sequence passed inoculum showed 99.8% nucleotide identity. Rabbit RNA (positive- negative-stranded) was detectable various tissues experimentally rabbits, indicating extrahepatic replication may be common. Thus, transmissible to macaques, which suggests a new source human infection.
cdc.gov
core.ac.uk
sci-hub.se 参考文章(34)
J. Geng, L. Wang, X. Wang, H. Fu, Q. Bu, Y. Zhu, H. Zhuang, Study on prevalence and genotype of hepatitis E virus isolated from Rex Rabbits in Beijing, China. Journal of Viral Hepatitis. ,vol. 18, pp. 661- 667 ,(2011) , 10.1111/J.1365-2893.2010.01341.X
C.G. Teo, Much meat, much malady: changing perceptions of the epidemiology of hepatitis E Clinical Microbiology and Infection. ,vol. 16, pp. 24- 32 ,(2010) , 10.1111/J.1469-0691.2009.03111.X
X.-J. Meng, P. G. Halbur, J. S. Haynes, T. S. Tsareva, J. D. Bruna, R. L. Royer, R. H. Purcell, S. U. Emerson, Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV Archives of Virology. ,vol. 143, pp. 1405- 1415 ,(1998) , 10.1007/S007050050384
Shuchin Tei, Naoto Kitajima, Kazuaki Takahashi, Shunji Mishiro, Zoonotic transmission of hepatitis E virus from deer to human beings The Lancet. ,vol. 362, pp. 371- 373 ,(2003) , 10.1016/S0140-6736(03)14025-1
S. A. Tsarev, S. U. Emerson, G. R. Reyes, T. S. Tsareva, L. J. Legters, I. A. Malik, M. Iqbal, R. H. Purcell, Characterization of a prototype strain of hepatitis E virus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 559- 563 ,(1992) , 10.1073/PNAS.89.2.559
X. J. Meng, Recent advances in Hepatitis E virus. Journal of Viral Hepatitis. ,vol. 17, pp. 153- 161 ,(2010) , 10.1111/J.1365-2893.2009.01257.X
William Batts, Susan Yun, Ronald Hedrick, James Winton, A novel member of the family Hepeviridae from cutthroat trout ( Oncorhynchus clarkii ) Virus Research. ,vol. 158, pp. 116- 123 ,(2011) , 10.1016/J.VIRUSRES.2011.03.019
Yansheng Geng, Chenyan Zhao, Aijing Song, Jinheng Wang, Xiao Zhang, Tim J. Harrison, Yan Zhou, Wenbo Wang, Youchun Wang, The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China Infection, Genetics and Evolution. ,vol. 11, pp. 476- 482 ,(2011) , 10.1016/J.MEEGID.2010.12.012
Nassim Kamar, Richard P. Bendall, Jean Marie Peron, Pascal Cintas, Laurent Prudhomme, Jean Michel Mansuy, Lionel Rostaing, Frances Keane, Samreen Ijaz, Jacques Izopet, Harry R. Dalton, Hepatitis E Virus and Neurologic Disorders Emerging Infectious Diseases. ,vol. 17, pp. 173- 179 ,(2011) , 10.3201/EID1702.100856
S. A. Tsarev, S. U. Emerson, T. S. Tsareva, P. O. Yarbough, M. Lewis, S. Govindarajan, G. R. Reyes, M. Shapiro, R. H. Purcell, Variation in Course of Hepatitis E in Experimentally Infected Cynomolgus Monkeys The Journal of Infectious Diseases. ,vol. 167, pp. 1302- 1306 ,(1993) , 10.1093/INFDIS/167.6.1302