Prejunctional Inhibitory Effects of Isoprostanes on Dopaminergic Neurotransmission in Bovine Retinae, In vitro
作者： Hong Liu , Min Zhao , Catherine A. Opere
DOI: 10.1007/S11064-007-9404-Z
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摘要: We investigated the effect of isoprostanes (IsoPs) on potassium (K+)-depolarization-evoked release [3H]dopamine from isolated bovine retinae. Isolated retinae were preloaded with and then prepared for studies using superfusion method. 8-iso(15R)PGF2α, 8-isoPGE2, 8-isoPGE1 8-isoPGF2α attenuated At a concentration 1 μM, rank order activity displayed by IsoP agonists was: 8-iso(15R)PGF2α > 8-isoPGE2 > 8-isoPGE1 > 8-isoPGF2α. Inhibition cyclooxygenase (COX) flurbiprofen reversed effects caused 8-isoPGE2 (10 nM 10 μM), 8-iso(15R)PGF2α (1 μM) (1 μM). Although EP1/EP2 antagonist, AH 6809 (10 μM) had no significant K+-induced release, it blocked inhibitory both (10 μM). In conclusion, IsoPs attenuate in retinae, presumably via an indirect action COX pathway leading to production prostanoids, which turn, activates EP receptors.
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