Pain Mechanisms and Centralized Pain in Temporomandibular Disorders

摘要: Until recently, most clinicians and scientists believed that the experience of pain is perceptually proportional to amount incoming peripheral nociceptive drive due injury or inflammation in area perceived be painful. However, many cases chronic have defied this logic, leaving perplexed as how patients are experiencing with no obvious signs periphery. Conversely, there who a and/or but little pain. What makes some individuals intense minimal stimulation others serious injury? It increasingly well accepted scientific community can generated maintained or, through other mechanisms, suppressed by changes central nervous system, creating complete mismatch between In fact, known condition where observed extent damage reproducibly engenders same level across individuals. Temporomandibular disorders (TMDs) exception. This review focuses on idea TMD range continuum-from those whose peripherally centralized (i.e., generated, exacerbated, system mechanisms). article uses conditions guide, it suggests mechanistic variability etiology has prevented us from adequately treating diagnosed condition. As field moves forward, will imperative understand each person's its own standpoint, which enable deliver personalized medicine eventually provide relief even recalcitrant cases.