High Mammographic Density in Long-Term Night-Shift Workers: DDM-Spain/Var-DDM

摘要: Background: Night-shift work (NSW) has been suggested as a possible cause of breast cancer, and its association with mammographic density (MD), one the strongest risk factors for scarcely addressed. This study examined NSW MD in Spanish women. Methods: The covered 2,752 women aged 45–68 years recruited 2007–2008 7 population-based public cancer screening centers, which included 243 who had performed at least year. Occupational data information on potential confounders were collected by personal interview. Two trained radiologist estimated percentage assisted validated semiautomatic computer tool (DM-scan). Multivariable mixed linear regression models random center–specific intercepts fitted using log-transformed dependent variable adjusting known confounding variables. Results: Having ever worked was not associated \( [{e^\beta }$ \):0.96; 95% confidence interval (CI), 0.86–1.06]. However, adjusted geometric mean more than 15 25% higher that those without history (MD >15 :20.7% vs. never :16.5%;\( {e^\beta \):1.25; CI,1.01–1.54). mainly observed postmenopausal participants (\( \):1.28; CI, 1.00–1.64). Among NSW-exposed women, ≤2 night-shifts per week 5 to nightshifts \):1.42; 1.10–1.84). Conclusions: Performing only cumulated exposure. These findings warrant replication futures studies. Impact: Our suggest could play role pathway between long-term cancer. Cancer Epidemiol Biomarkers Prev; 26(6); 905–13. ©2017 AACR .