Canertinib induces ototoxicity in three preclinical models
作者： Jian Tang , Yi Qian , Hui Li , Benjamin J. Kopecky , Dalian Ding
DOI: 10.1016/J.HEARES.2015.07.002
关键词:
摘要: Abstract Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing impairment in mice. Dysregulation of the same signaling pathway in humans is involved in certain types of cancers such as breast cancer or non-small cell lung cancer (NSCLC). A new irreversible pan-ERBB inhibitor, canertinib, has been tested in clinical trials for the treatment of refractory …
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