Aggressive psammomatoid ossifying fibromas of the sinonasal region: a clinicopathologic study of a distinct group of fibro-osseous lesions.

摘要: Background. Psammomatoid ossifying fibromas represent a unique subset of fibro-osseous lesions the sinonasal tract. They have distinctive histomorphologic features and tendency toward locally aggressive behavior, including invasion destruction adjacent anatomic structures. Methods. Seven cases psammomatoid tract were identified in files Otolaryngic Tumor Registry at Armed Forces Institute Pathology. Medical records, clinical history, location lesions, radiographs, treatment, follow-up reviewed each case. Follow-up information was available all cases. Results. Four patients male three female. The patients' ages ranged from 5 to 54 years (median age, 33 years). Symptoms included facial swelling, nasal obstruction, pain, sinusitis, headache, proptosis. Radiographic studies confirmed presence an osseous and/or soft tissue mass varying appearance well demarcated without or erosion invasive with bone intracranial extension. Sites involvement cavity paranasal sinuses, particularly ethmoid maxillary sinuses. Often, more than one sinus involved extension disease orbit, nasopharynx, palate, anterior cranial fossa. histologic characterized by small mineralized (psammomatoid) bodies admixed cellular stroma variable amount myxomatous material scattered giant cells. Confusion other tumors may occur resulting too limited management. En bloc surgical excision is treatment choice prove curative. Aggressive behavior recurrence(s) into structures occurred. At time this writing, are alive over periods ranging 6 months 7 years. Conclusions. Gnathic midfacial proliferations diverse group lesions. A these predilection for identified. These their histology, ossicles growth. Complete removal choice.