Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats:

摘要: Twenty days of complex motor skill training in adult rats was previously demonstrated to rehabilitate performance deficits induced by binge alcohol exposure neonatal rats. This follow-up study evaluated morphological plasticity the paramedian lobule cerebellum (PML) using same treatment and regimens. On postnatal (PD) 4-9, female Long-Evans were given either (Alcohol Exposure - AE, 4.5 g/kg/day via artificial rearing), gastrostomy control (GC) rearing procedures, or reared normally as suckle controls (SC). After weaning, all housed two three per cage. At 180 old, randomly assigned a rehabilitation condition (RC: 20 training), an inactive (IC: remained their home cage). The AE delayed acquiring training, but there no group differences over last 2 weeks training. Unbiased stereological techniques used evaluate PML volume, Purkinje cell parallel fiber synapse density. Although total volume significantly reduced rats, resulted significant increase molecular layer groups. RC animals from SC groups had more synapses than corresponding IC animals. These data support hypothesis that 'rehabilitative' stimulates synaptogenesis PML, neurons survive early insult are capable substantial experience-induced plasticity.