Intratumoral heterogeneity of the distribution of kinetic parameters in breast cancer: comparison based on the molecular subtypes of invasive breast cancer
作者： Ken Yamaguchi , Hiroyuki Abe , Gillian M. Newstead , Ryoko Egashira , Takahiko Nakazono
DOI: 10.1007/S12282-013-0512-0
关键词:
摘要: To evaluate the distribution pattern of kinetic parameters in breast cancers with various molecular subtypes. This study was approved by institutional review board and compliant HIPAA. We classified 192 invasive 186 patients into four subtypes using hormone receptor (HR) human epidermal growth factor 2 (HER2) results evaluated (percent volume types relative to tumor volume) In delayed phase, all three parameter (persistent, plateau, washout pattern) were observed each subtype without any dominant type parameter. The percentages HR+ HER2− triple negative (TN) tended be lower than those other cancers. Each cancer showed a heterogeneous dynamic-contrast magnetic resonance imaging (MRI). HR+/HER2− TN had relatively pattern. When manual assessment is performed, close attention should paid order identify malignant pattern, particularly cancer.
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