Physiological factors influencing capillary growth.

摘要: (1) Angiogenesis (growth of new capillaries from an existing capillary bed) may result a mismatch in microvascular supply and metabolic demand (metabolic error signal). Krogh examined the distribution number to explore correlation between O(2) delivery consumption. Subsequently, heterogeneity angiogenic response within muscle has been shown reflect either differences fibre type composition or mechanical load. However, local control leads targetted angiogenesis vicinity glycolytic types following stimulation, oxidative fibres endurance training, while spacing is maintained during ontogenetic growth. (2) Despite limited microscopy resolution lack specific markers, Krogh's interest structure wall paved way for understanding mechanisms be influenced by perivascular stromal cells (fibroblasts, macrophages pericytes) altered activity, likely acting as source chemical signals modulating growth such vascular endothelial factor. In addition, haemodynamic factors shear stress stretch play significant role adaptive remodelling microcirculation. (3) Most indices capillarity are highly dependent on size, resulting possible bias because scaling. To examine consequences distribution, it therefore helpful quantify area tissue supplied individual capillaries. This allows spatial limitations inherent most models oxygenation overcome generating alternative approach cylinder, domain, improve descriptions intracellular oxygen diffusion.